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Methodological challenges to human medical study

null

《医学前沿（英文）》 2014年第8卷第3期页码 328-336 doi: 10.1007/s11684-014-0359-6

摘要：

With the transformation of modern medicinal pattern, medical studies are confronted with methodological challenges. By analyzing two methodologies existing in the study of physical matter system and information system, the article points out that traditional Chinese medicine (TCM), especially the treatment based on syndrome differentiation, embodies information conception of methodological positions, while western medicine represents matter conception of methodological positions. It proposes a new way of thinking about combination of TCM and western medicine by combinating two kinds of methodological methods.

关键词： medical paradigm traditional Chinese medicine western medicine scientific view scientific methodology

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复杂性工程技术问题研究实践与科学方法论思考

李世煇

《中国工程科学》 2002年第4卷第11期页码 71-81

摘要：

简介了在复杂性工程技术问题研究中典型信息法的若干成功应用，并以天文、地质、生物学等以复杂系统为研究对象的学科中典型信息法的应用实例，说明其应用的广泛性；阐述了典型信息法的概念，并简述了对有关科学方法论问题的几点思考。

关键词：复杂性工程技术问题实践科学方法论还原论与整体论结合典型信息法

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鼠疫病史研究的方法论省思

符友丰

《中国工程科学》 2007年第9卷第9期页码 19-29

摘要：

通过19世纪最后20余年间中国、日本、荷兰，包括1929年诺贝尔生理学和医学奖得主爱克曼发现beriberi，中国专家吴存甫、罗汝兰出版《鼠疫汇编》，著名学者耶尔森发现鼠疫杆菌等历史过程的回顾，探讨了对当代学术思想的影响；在进一步论证古典脚气与鼠疫流行同一性的基础上，阐述了鼠疫流行对中国明清温疫与日本江户–明治脚气盛行的内在联系；分析了中西医家在宏观整体论与微观还原论等不同方法论指导下取得的历史成就与经验教训；结合百余年来有关病史悬案在中、英两种大百科全书注释中留下的疑云，剖析了近代医学发展史上涉及的科学研究方法论与医学发展复杂性话题。

关键词：比较医学史日本鼠疫史脚气医学方法论复杂性探索爱克曼廖育群

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Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis

《化学科学与工程前沿（英文）》 2022年第16卷第2期页码 221-236 doi: 10.1007/s11705-021-2061-y

摘要： To study the dynamic behavior of a process, time-resolved data are collected at different time instants during each of a series of experiments, which are usually designed with the design of experiments or the design of dynamic experiments methodologies. For utilizing such time-resolved data to model the dynamic behavior, dynamic response surface methodology (DRSM), a data-driven modeling method, has been proposed. Two approaches can be adopted in the estimation of the model parameters: stepwise regression, used in several of previous publications, and Lasso regression, which is newly incorporated in this paper for the estimation of DRSM models. Here, we show that both approaches yield similarly accurate models, while the computational time of Lasso is on average two magnitude smaller. Two case studies are performed to show the advantages of the proposed method. In the first case study, where the concentrations of different species are modeled directly, DRSM method provides more accurate models compared to the models in the literature. The second case study, where the reaction extents are modeled instead of the species concentrations, illustrates the versatility of the DRSM methodology. Therefore, DRSM with Lasso regression can provide faster and more accurate data-driven models for a variety of organic synthesis datasets.

关键词： data-driven modeling pharmaceutical organic synthesis Lasso regression dynamic response surface methodology

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工程管理方法论

何继善,徐长山,王青娥,郭峰

《中国工程科学》 2014年第16卷第10期页码 4-9

摘要：

本文按三个层次构建工程管理方法论的框架体系：工程管理哲学方法论、工程管理一般方法论和工程管理具体方法论。将实事求是方法、矛盾分析方法、知行统一方法、真理尺度和价值尺度统一方法和辩证思维方法作为工程管理哲学方法论的主要方法。工程管理一般方法论以系统科学方法、信息科学方法和数学方法为代表。案例研究方法等九种方法则是工程管理具体方法论的主要方法。这种框架不是绝对的，如系统工程方法和项目管理方法都向三个层次延伸。

关键词：工程管理方法论哲学方法论一般方法论具体方法论

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Search for a natural scientific measure of economy

John E COULTER

《环境科学与工程前沿（英文）》 2011年第5卷第1期页码 111-118 doi: 10.1007/s11783-011-0285-7

摘要： Through human history, wealth has been measured in grain, gold, and, now, dollars. Though counterfeiting of coins and notes goes back a long way, it is only with electronic financial accounting in a global economy tainted by toxic loans and imaginary funds that there is an urgency to search for a realistic objective way to monitor and regulate what we are doing to our Earth and ourselves. Various schemes using analysis of utility functions, oil equivalents, entropy, energy, and other units have been tried and, while helping to understand some basic processes and flows, have always been swamped by the machinations of financiers and the attention big sums of money attract. Now, the concept of exergy, pioneered in Eastern Europe in the 1950s, is being researched, developed, and applied, especially in China, driven by the desperation to measure the reality beyond the twin specters of global financial and environmental crises. A rough inventory of the matter in the biosphere at the coordinate details of an angstrom and an appreciation of how humans harness and manipulate electromagnetic forces can be enlightening as to what is and is not sustainable. Without that understanding, any financial estimate and proposed stimulus packages or IMF reform will be wildly wrong and may even be headed in the wrong direction.

关键词： climate change financial crisis energy exergy environment

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of a combined approach for improvement and optimization of karanja biodiesel using response surface methodology

Sunil DHINGRA, Gian BHUSHAN, Kashyap Kumar DUBEY

《能源前沿（英文）》 2013年第7卷第4期页码 495-505 doi: 10.1007/s11708-013-0267-5

摘要： This paper described the production of karanja biodiesel using response surface methodology (RSM) and genetic algorithm (GA). The optimum combination of reaction variables were analyzed for maximizing the biodiesel yield. The yield obtained by the RSM was 65% whereas the predicted value was 70%. The mathematical regression model proposed from the RSM was coupled with the GA. By using this technique, 90% of the yield was obtained at a molar ratio of 38, a reaction time of 8 hours, a reaction temperature of 40 oC, a catalyst concentration of 2% oil, and a mixing speed of 707 r/min. The yield produced was closer to the predicted value of 94.2093%. Hence, 25% of the improvement in the biodiesel yield was reported. Moreover the different properties of karanja biodiesel were found closer to the American Society for Testing & Materials (ASTM) standard of biodiesel.

关键词： optimization of karanja biodiesel genetic algorithm (GA) response surface methodology (RSM) percentage improvement in the biodiesel yield properties of biodiesel

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Rethinking the tendering frameworks of construction contractors in the context of a soft systems methodology

Stephen URQUHART, Andrew WHYTE

《工程管理前沿（英文）》 2018年第5卷第3期页码 369-380 doi: 10.15302/J-FEM-2018019

摘要：

Limited research has been conducted on the internal tendering procedures (ITP) of construction contractors because of the commercially sensitive and confidential nature of the subject matter. This limitation explains the reluctance of contractors to undergo interviews. Existing research (outside bid/no-bid and margin decision factor identification and subsequent decision modeling development) only begins to provide insights into key tendering stages, particularly around risk assessments and corporate review processes. Early research suggested one to three review stages. However, when considering the whole work procurement process from prospect identification to contract execution, five to seven series of reviews can be arguably applied by some contractors, wherein some reviews stepped through several layers of internal senior management. Tendering processes were presented as flowchart models that traditionally follow “hard” system (rectangular shapes and straight line arrows) steps, which suggest that a precise process also leads to precise results. However, given that contractors do not win every tender they submit, the process is less precise than that suggested in rigidly structured flowcharts. Twenty-five detailed semi-structured interviews were held with purposely selected high-profile publicly and privately owned construction companies in Australia with significantly varied turnovers. Analyses show that contractors are concerned about the negative effects of increasing corporate governance demands, with many stating that people involved are the most critical element to tendering success. A new way of presenting the ITP of contractors is assessed using a soft systems methodology (SSM) approach. SSM offers an alternative way of considering human interaction challenges within the ITP of contractors, which needs to be tested with the industry. The format graphics of SSM guidelines are presented as a way of offering contractors a different approach, which may assist individuals who are looking to re-structure their tendering activities in a more humanistic and less rigid procedural approach.

关键词： contractor corporate governance humanistic risk soft systems methodology tendering procedures

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Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

《医学前沿（英文）》 2011年第5卷第2期页码 157-162 doi: 10.1007/s11684-011-0128-8

摘要： At present, clinical pathway has become one of the most important health care reform measures in many countries. In this study, the authors introduced basic concepts and explored the application of the clinical pathway of evidence-based Chinese medicine incorporated with the methodology from the concepts of management, evidence-based medicine, operational research and health economics. Such concepts provide examples and experiences, on which the application of clinical pathway in Chinese medicine practice in China can be based.

关键词： evidence-based medicine clinical pathway methodology concept technical difficulty

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Optimization of the O/HO process with response surface methodology for pretreatment of mother liquor

《环境科学与工程前沿（英文）》 2021年第15卷第4期 doi: 10.1007/s11783-020-1371-5

摘要：

• Real ML-GFW with high salinity and high organics was degraded by O₃/H₂O₂ process.

关键词： High salinity High organic matters Gas field wastewater O₃/H₂O₂ Response surface methodology

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A conceptual methodology for simultaneous optimization of water and heat with non-isothermal mixing

Yanlong Hou, Wanni Xie, Zhenya Duan, Jingtao Wang

《化学科学与工程前沿（英文）》 2017年第11卷第2期页码 154-165 doi: 10.1007/s11705-016-1593-z

摘要： A new conceptual methodology is proposed to simultaneously integrate water allocation and energy networks with non-isothermal mixing. This method employs a simultaneous model and includes two design steps. In the first step, the water allocation network (WAN), which could achieve the targets of saving water and energy, is obtained by taking account the temperature factor into the design procedure. The optimized targets of both freshwater and energy are reached at this step which ensures this approach is a simultaneous one. In the second step, based on the obtained WAN, the whole water allocation and heat exchange network (WAHEN) is combined with the non-isothermal mixing to reduce the number of heat exchangers. The thus obtained WAHEN can achieve three optimization targets (minimization of water, energy and the number of heat exchangers). Furthermore, the effectivity of our method has been demonstrated by solving two literature examples.

关键词： simultaneous integration non-isothermal mixing multi-target optimization water and energy networks

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A highly efficient methodology for the preparation of

Yongxin Zhang, Shucheng Wang, Yaodong Huang

《化学科学与工程前沿（英文）》 2021年第15卷第3期页码 679-686 doi: 10.1007/s11705-020-1979-9

摘要： A convenient and highly efficient method is described for the synthesis of -methoxycarbazole derivatives, including those with sterically demanding, benzannulated, or strongly electron-donating or -withdrawing substituents. Various -methoxycarbazole derivatives were directly prepared in good-to-moderate yields by the Pd (dba) CHCl /9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene-catalyzed reactions of the corresponding dibromobiphenyl compounds and methoxya-mine. Based on this methodology, the first total synthesis of 3,3′-[oxybis(methylene)]bis(9-methoxy-9 -carbazole), an antimicrobial dimeric carbazole alkaloid previously isolated from the stem bark of , was achieved in 18% yield over seven steps from 1,2-dibromobenzene.

关键词： N-methoxyl carbazole dimeric N-methoxyl carbazole alkaloid total synthesis double N-arylation of methoxyamine

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Complex Financial Information System Engineering Management from the Perspective of Meta-synthesis Methodology—with

Hong-feng Chai,Quan Sun

《工程管理前沿（英文）》 2016年第3卷第4期页码 404-413 doi: 10.15302/J-FEM-2016037

摘要： The paper empirically studies the engineering practices of the national currency circulation information system-China Union Pay’s Bankcard Information Exchange System. By integrating the meta-synthesis methodology and the financial information system engineering, the paper proposes basic principles and processes of the giant and complex financial information system engineering management, and further explores its paradigm and toolkit.

关键词： financial information system meta-synthesis methodology bank card information exchange

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创新工程技术支撑科学发展

杜祥琬

《中国工程科学》 2009年第11卷第4期页码 4-8

摘要：

回顾了近年特别是2008年中国在信息、能源、制造业及探索宏观、微观世界等领域所取得的重大科学技术进步和工程创新成就；指出了严重自然灾害对科学技术和工程的检验与启示；提出了我国工程科技界值得思考的几个问题，展望了未来我国工程技术的创新使命。

关键词：技术工程创新科学发展

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Machine learning-based solubility prediction and methodology evaluation of active pharmaceutical ingredients

《化学科学与工程前沿（英文）》 2022年第16卷第4期页码 523-535 doi: 10.1007/s11705-021-2083-5

摘要： Solubility has been widely regarded as a fundamental property of small molecule drugs and drug candidates, as it has a profound impact on the crystallization process. Solubility prediction, as an alternative to experiments which can reduce waste and improve crystallization process efficiency, has attracted increasing attention. However, there are still many urgent challenges thus far. Herein we used seven descriptors based on understanding dissolution behavior to establish two solubility prediction models by machine learning algorithms. The solubility data of 120 active pharmaceutical ingredients (APIs) in ethanol were considered in the prediction models, which were constructed by random decision forests and artificial neural network with optimized data structure and model accuracy. Furthermore, a comparison with traditional prediction methods including the modified solubility equation and the quantitative structure-property relationships model was carried out. The highest accuracy shown by the testing set proves that the ML models have the best solubility prediction ability. Multiple linear regression and stepwise regression were used to further investigate the critical factor in determining solubility value. The results revealed that the API properties and the solute-solvent interaction both provide a nonnegligible contribution to the solubility value.

关键词： solubility prediction machine learning artificial neural network random decision forests